ANTIMICROBIAL SUSCEPTIBILITY PROFILE OF BACTERIAL PATHOGENS ISOLATED FROM URINARY TRACT INFECTIONS
Abstract
Urinary tract infections (UTIs) are among the most prevalent bacterial diseases in the world and constitute a significant public health concern due to the increasing prevalence of antimicrobial resistance among uro-pathogens. The present study aimed to determine the antimicrobial susceptibility profile of bacterial pathogens isolated from patients with urinary
tract infections and to identify the most prevalent uropathogens responsible for these infections. This retrospective observational study was conducted using microbiological laboratory records from patients suspected of UTIs. A total of 80 culture-positive urine samples were included in the analysis. Bacterial isolates were identified using standard microbiological techniques, and antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method in accordance with Clinical and Laboratory Standards Institute guidelines. Descriptive statistical methods were
used to determine the frequency and percentage distribution of bacterial isolates and antibiotic susceptibility patterns. Chi-square analysis was used to examine the association between gender and bacterial distribution, while Pearson correlation and linear regression analyses were performed to evaluate the relationship between patient age and antimicrobial resistance. The results showed that female patients accounted for the majority of cases (65%). Escherichia coli was the most predominant pathogen (45%), followed by Klebsiella spp., Proteus spp., Pseudomonas spp., and Staphylococcus aureus. Nitrofurantoin showed the highest sensitivity among tested antibiotics, whereas Ampicillin
demonstrated the highest resistance rate. These findings highlight the importance of continuous monitoring of antimicrobial susceptibility patterns to guide appropriate antibiotic therapy and improve the management of urinary tract infections.
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